Study Design: Observational Study
Disease Area: Cancer Blood
Funder: Blood Cancer UK
Sponsor: University of Hull
Chief Investigator: Dr David Allsup
Trial Registration: NCT04182074

Leukaemia in Pregnancy Study (LIPS)


Acute leukaemia (AL) is an aggressive but potentially curable cancer that can affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the mother's survival through delaying treatment, against the potential harm to the foetus through exposure to cancer drugs. Reports suggest that, providing the first trimester is avoided, successful treatment of AL during pregnancy is possible, and considered safe. However, there is currently no standard approach to treatment of these women.

This observational study will establish a UK-wide registry to specifically monitor the management of AL, or high-risk myelodysplasia (MDS) in pregnancy, and the associated outcomes for both the mother and neonate. It will also document pregnancies conceived post treatment. An initial retrospective component will also collect data on cases since August 2009.

Ultimately, this study will be used as a reference from which to derive firm recommendations for the management of these patients, to better inform future patterns of care.

Accessing cases without consent

For historical cases where the patient is no longer in active follow-up with the hospital, HHTU have applied for permission to access data without consent. For more details about this, please refer to the Patient Notification and Privacy Notice below. If you think that you may have been an eligible case, this explains how you can find out if you have been included in the dataset and how to raise any questions or objections you may have on the use of your information.

If you are a patient or a member of the public with experience in this area and would be interested in joining a group to help shape the ongoing development of the database and how we handle this data, please contact Matt Northgraves (01482 463373) who would be happy to discuss this with you.

Chief Investigator

Dr David Allsup Senior Lecturer in Haematology - Hull York Medical School

HHTU Study team

Dr Matthew Northgraves - Trial Manager
John Turgoose - Information Systems Manager
Prof Judith Cohen - Director
Dr Chao Huang - Statistician
Dr Lukas Pitel - Statistician


Dr Sahra Ali Consultant Haematologist - Retired

Email address

Participating Sites and their Project Investigators

  • Hull University Teaching Hospitals NHS Trust Dr David Allsup
  • University Hospital of Wales, Cardiff Dr Steve Knapper
  • NHS Greater Glasgow and Clyde Dr Mhairi Copland
  • South Tees Hospitals NHS Foundation Trust Dr Sarah Essex
  • Leeds Teaching Hospitals NHS Trust Dr Anjum Kahn
  • Nottingham Teaching Hospitals NHS Trust Dr Julie Kenny
  • UCL Hospitals NHS Foundation Trust Dr Panos Kottaridis


Northgraves M, Allsup D, Cohen J, Huang C, Turgoose J, Ali S (2022) A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol. PLoS ONE 17(2): e0263195.