Study Design: Three-stage, sequential, mixed-methods project with a series of six interlinked work packages
Disease Area: Endocrinology
Funder: NIHR HSDR
Sponsor: University of Sheffield
Chief Investigator: Dr Charlotte Elder & Prof Miguel Debono
Evaluating the implementation and uptake of Waking Salivary Cortisone: a new home-based test for Adrenal Insufficiency
(RE-SCAIT)
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Project overview
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Trial Team
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Participating Sites
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Privacy Notice
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Dissemination
Summary
The current diagnostic pathway for adrenal insufficiency (AI) entails hospital-based tests (early morning cortisol (EMC) or Short Synacthen Test (SST)) which are expensive and resource-intensive, necessitating skilled nurses and a daycare admission. An alternative home-based waking salivary cortisone (WSC) test has been implemented in clinical care in both the adult and children’s hospitals in Sheffield. This has been shown to be an accurate test, is preferred by patients and is cheap and easy to perform. The RE-SCAIT study aims to implement the WSC test in 4 geographically disparate NHS Trusts and to evaluate the success of this implementation.
What we plan to do
Project Aim:
To evaluate the implementation and uptake of WSC for adrenal insufficiency testing in adults and children referred for diagnosis of adrenal insufficiency in the NHS.
Objectives:
- To develop an implementation strategy for WSC for adults and children.
- To identify adaptations needed to improve inclusiveness.
- To measure clinician uptake of WSC as a replacement for conventional testing.
- To identify facilitators and barriers to implementation in different types of hospital.
- To assess the costs of offering WSC versus current testing for adrenal insufficiency.
- To refine the implementation strategy to facilitate widespread NHS rollout of WSC, if appropriate.
Chief Investigator
Dr. Charlotte Eldar Senior Clinical Lecturer in Paediatric Endocrinology – University of Sheffield
Prof. Miguel Debono Clinical Director, Consultant and Honorary Professor in Endocrinology – Sheffield Teaching Hospitals NHS Foundation Trust
HHTU Study team
Kathryn Date - Trial Manager
Judith Cohen - HHTU Director
John Turgoose - Information System Manager
Collaborators
Prof Alicia O’Cathain Professor of Health Services Research – University of Sheffield
Dr Kate Fryer Research Associate – University of Sheffield
Prof John Newell-Price Professor of Endocrinology – University of Sheffield
Prof Richard Ross Emeritus Professor of Endocrinology – University of Sheffield
Ms Sarah Davis Senior Research Fellow in Health Economics – University of Sheffield
Prof Mark Pearson Professor of Implementation Science – University of Hull
Dr Chao Huang Reader in Statistics – University of Hull
Prof Brian Keevil Consultant Clinical Scientist – Manchester University Hospital NHS Foundation Trust
Dr Liz Croot Senior Lecturer – University of Sheffield
Dr Sharon Caunt Directorate Research Coordinator – Sheffield Teaching Hospitals NHS Foundation Trust
Mr Stewart Featherby – PPI representative
Miss Laura Duffield – PPI representative
Email address
hhtuenquiries@hyms.ac.uk
Participating Sites and their Project Investigators
- King’s College Hospitals NHS Foundation Trust
- Leeds Teaching Hospitals NHS Trust
- Royal Cornwall Hospitals NHS Trust
- University of Hospitals of Leicester NHS Trust
Watch this space.
Collaborators
