STARLIT 1

Study Design: CTIMP
Disease Area: Endocrinology
Funder: Medical Research Council
Sponsor: Sheffield Children’s NHS Foundation Trust
Chief Investigator: Dr Charlotte Elder

Salivary Test of Adrenal Response to Liquid Intranasal Tetracosactide

STARLIT 1

ANALYSIS/PUBLICATION

Summary

Adrenal insufficiency (AI) is the medical term for the body’s adrenal glands not producing enough of the vital stress hormone, cortisol. Cortisol is usually measured in blood samples, but we are developing ways to diagnose adrenal insufficiency by measuring cortisol (and a very similar hormone, cortisone) in saliva samples, which will lead to needle-free testing.

There will be 3 parts to the STARLIT programme:

In this study, (STARLIT-1), we are looking to see whether there are big differences in blood and saliva cortisol and cortisone levels within the same individual when samples are taken very close together in healthy adults.

STARLIT-2 will compare the blood sample test to the needle-free test in healthy volunteers, and then STARLIT-3 will look at the effectiveness of our needle-free test in patients with AI.

Chief Investigator

Charlotte Elder - University of Sheffield

HHTU Study team

Kathryn Date - Trial Manager
Vic Christie - Trial Co-ordinator
Judith Cohen - Co-Investigator, HHTU Director
Bronwen Williams - Operations Manager
John Turgoose - Information Systems Manager
Sarah Sumpter - Senior Data Manager
Steve Howe - Data Manager
Kerri Morris - Trial Administrator

Collaborators

Richard Ross - Co-Investigator - University of Sheffield
Simon Dixon - Co-Investigator - University of Sheffield
Jane Fearnside - PPI Lead - University of Sheffield
Rosie Taylor - Statistician - University of Sheffield 
Nicola Galley - Commercialisation Manager - University of Sheffield 
Evy De Leenheer - Project Manager - University of Sheffield 
Miguel Debono - Co-Investigator - Sheffield Teaching Hospitals
Keith Pugh  - Sponsor Representative - Sheffield Childrens Hospital

Email address

starlit@hyms.ac.uk

Participating Sites 

  • Sheffield Children's Hospital (Sheffield Children's NHS Foundation Trust)

To find out more about the study you can read the STARLIT 1 Participant Information Leaflet here. 

Please view the STARLIT 1 privacy notice here.